Urotol

Уротол Drug photo

The description is actual on 12.09.2015

  • Latin name: Urotol
  • ATH code: G04BD07
  • Active ingredient: Tolterodin
  • Producer: Zentiva k.s (Czech Republic)

Structure

1 tablet contains 1 or 2 mg of active agent of a tolterodin of hydrogen of tartrate.

Auxiliary components are: cellulose microcrystallic, titanium dioxide, the macrogoal 6000, silicon dioxide, talc, a gipromelloza krakhmalglikolit sodium, the stearylfumarating sodium.

Release form

In the tableted form, in blisters on 14 pieces, and also capsules of the prolonged action Urotol SR.

Pharmacological action

Urological means.

Pharmacodynamics and pharmacokinetics

The operating component – tolterodin. Medicine improves the urodynamic. Active agent is a blocker of muskarinovy receptors, and works purposefully for muscles of a bladder. Under the influence of a medicine the average volume of urine decreases, the incontience of urine is eliminated and the frequency of desires to an urination decreases. Active component does not influence Q-T an interval.

The expressed effect of drug Urotol is shown by the end of the 4th week of therapy. Tolterodin is well adsorbed in the alimentary system, the concentration peak in plasma is registered in 1-3 hours. The operating component is metabolized to the main metabolite and several inactive substances which are removed by kidneys. At persons, with the expressed pathology of hepatic system, increase of level of a neizmenenenny tolterodin in plasma is observed. At diseases of kidneys time of semi-removal of a tolterodin increases.

Indications to use

Urotol appoint to patients who suffer from multiple imperative desires to an urination.

The medicine is applied at a highly active bladder, at an urine incontience.

Contraindications

Urotol do not appoint at intolerance of a tolterodin, at an urination delay, the heavy course of ulcer colitis, closed-angle glaucoma, toxic megacolon.

In pediatric practice do not appoint drug Urotol. The application instruction recommends to apply with care tolterodin at neuropathy, at diseases of renal system and a liver, at an intestines hypoperistalsis, and also to patients with high risk of development of a myasthenia Gravis ("muscular powerlessness").

At treatment of patients who receive antiaritmik at registration of the extended interval Q-T, extra care is required. Inadmissibly during treatment to manage motor transport and other dangerous mechanisms.

Side effects

Frequent undesirable reactions: a reduced slezootdeleniye, dispepsichesky frustration, dryness in a mouth. Increased fatigue and disturbance of memory is less often observed.

Central nervous system: accommodation change, the expressed disorientation, vertigo, confusion of consciousness, disturbance of visual perception, the increased drowsiness, headaches, hallucinations.

Alimentary system: the strengthened meteorism, pains in epigastric area, locks (because of decrease in a vermicular movement of intestines), a gastroesophageal reflux, dryness in a mouth. Seldom increase in body weight and development of a diarrheal syndrome is registered.

Changes from heart and vascular system: feeling of a cardiopalmus, reddening of an upper body and face skin, tachycardia.

At some patients allergic answers in the form of dermatitis, the small tortoiseshell are noted. Seldom the Quincke's edema and anaphylactoid reactions develops.

Seldom dementia symptoms become aggravated, retrosternal pains, morbidity at an urination are registered, dryness of integuments, an exacerbation of chronic bronchitis, puffiness, an urination delay.

Urotol, application instruction (Way and dosage)

Drug is accepted entirely, inside. Selection of a dose by division of a tablet is inadmissible. Medicine can be accepted irrespective of meal. Duration of therapy is determined only by the attending physician.

At an urine incontience, a highly active bladder appoint 2 mg twice a day. At bad portability of a tolterodin the scheme can be changed: on 1 mg twice a day. At diseases of kidneys and hepatic system, at reception of strong CYP-3A4 inhibitors, the daily dose is reduced to 2 mg.

Urotol is recommended to take medicine within 6 months. If necessary reception of a tolterodin can be continued after half a year.

Overdose

At one-time reception of 12,8 mg of a tolterodin morbidity of desires to an urination is registered, accommodation is broken.

Overdose signs: mydriasis, breath disturbance, tachycardia, spasms, nervous and contagious excitation, delay of an urination, hallucination.

The antidote is not developed. Reception of enterosorbents, a gastric lavage, carrying out a symptomatic treatment is recommended.

At development of hallucinations, overexcitation and other central anticholinergic effects apply physostigmine.

At a convulsive syndrome enter benzodiazepines.

At tachycardia and change of breath hold events for recovery of breath and apply beta adrenoblockers.

At development of a mydriasis against reception of high doses of drug Urotol appoint drops for eyes with Pilocarpinum.

At a long delay of an urination catheterization is carried out.

Interaction

The medicines making anticholinergic impact strengthen Urotol's action and increase risk of development of undesirable and side reactions.

Tolterodin reduces efficiency of prokinetics.

Agonists of muskarinovy receptors slow down effect of drug.

Unacceptably simultaneous treatment by antifungal means (itrakonazol, ketokonazol, Miconazolum) and makrolidny antibiotics (klaritromitsin, erythromycin).

Clinically significant pharmacological interaction at simultaneous therapy by oral contraceptives and warfarin is not registered.

Terms of sale

Urotol can buy in a drugstore, having shown the prescription form.

Storage conditions

Without special storage conditions. In the place, unavailable to children.

Period of validity

No more than two years.

Special instructions

Before purpose of a medicine it is necessary to exclude organic changes which can lead to imperative desires on an urination.

To women Urotol is recommended to apply reliable methods of contraception for the entire period of therapy by drug.

Medicine can break accommodation and speed of psychomotor reactions that limits its use at control of difficult mechanisms, motor transport.

To children

Efficiency and safety of use of a tolterodin for children is not studied.

Coincidence on the ATH code of the 4th level:

Analogs it is possible to call drugs: Detruzitol, Tolterodin, Roliten.

About Urotole

Medicine is symptomatic, that is cleans only manifestations, but does not work with the reasons of diseases. Can begin to work not at once. About Urotole at forums point out good tolerance of a medicine.

Urotol's price where to buy

Urotol's price depends on pharmacy chain and averages 450-1100 rubles.

Zdravzona

  • Urotol of 2 mg No. 56 of a tabletkizentiv
  • Urotol of 1 mg No. 56 of a tabletkizentiv

Drugstore of IFC

  • Urotol tbl p / about 2 mg No. 56, Zentiva A.S.Chekhiya
  • Urotol tbl p / about 1 mg No. 56, Zentiva A.S.Chekhiya
to show still

Apteka24

  • Urotol of a tablet coated 2 mg No. 56zentiva International a.o. (Slovakia)

Paniapteka

  • Urotol of the tab. p / about 2 mg No. 56

BIOSPHERE

  • Urotol of 1 mg No. 56 tabl.p.p.o. Zentiva of ampere-second. (Czech Republic)
  • Urotol of 2 mg No. 56 tabl.p.p.o. Zentiva of ampere-second. (Czech Republic)
to show still
Section: Urological
in more detail

Education: Graduated from the Bashkir state medical university majoring in "Medical business". In 2011 gained the diploma and the certificate in Therapy. In 2012 received 2 certificate and the diploma in "Functional diagnosis" and "Cardiology". In 2013 completed courses on "Topical issues of otorhinolaryngology in therapy". In 2014 completed advanced training courses in "A clinical echocardiography" and courses in "Medical rehabilitation".

Experience: From 2011 to 2014 the Policlinic No. 33 Ufa worked as the therapist and the cardiologist in MBUZ. Since 2014 the Policlinic No. 33 Ufa works as the cardiologist and the doctor of functional diagnosis in MBUZ.

PAY ATTENTION! Information on drugs on the website is help generalizing, collected from public sources and can form the basis for making decision on use of medicines it is not aware of treatment. Before medicine use Urotol surely consult with the attending physician.