Вальпарин Drug photo

The description is actual on 02.08.2016

  • Latin name: Valparin
  • ATH code: N03AG01
  • Active ingredient: Valproic acid (Valproic acid)
  • Producer: TORRENT PHARMACEUTICALS, Ltd. (India)


Tablets: sodium Valproatum, valproic acid, ethyl cellulose, silicon dioxide colloid, gidroksipropilmetiltsellyuloza, hydrate of dioxide flints, sodium saccharinate, glycerin; titanium dioxide, eudragit, polyethyleneglycol, talc.

Solution for intake: sodium Valproatum, sodium saccharin, methylhydroxybenzoate, propilgidroksibenzoat, sodium chloride, likazin, sodium cyclomate, flavoring additives, the water purified.

Release form

Tablets with the prolonged action (Valparin of XP500, Valparpin XP300) in a film cover of a round form, biconvex white color in a strip from aluminum foil on 10 tablets in cardboard packaging No. 30 or 100.

Syrup of 40 mg/ml for children colourless with peach taste and aroma in the glass darkened bottles on 100 ml with the measured syringe in cardboard packaging.

Pharmacological action


Pharmacodynamics and pharmacokinetics


Drug with antiepileptic action, possesses myorelaxation and sedation. The mechanism of action consists in GAMK-transferase inhibition in a brain under the influence of valproic acid and reduction of the return capture of GAMK that leads to decrease in excitability of motive zones of a brain and reduction of manifestation of a convulsive component. Therapeutic action consists in normalization of the mental status of patients with various types of epilepsy and their mood, renders antiepileptic activity. Has therapeutic no significant sleeping pill and sedative effect, does not oppress function of a respiratory center, does not influence the ABP, function of kidneys, ChSS and body temperature.


Drug is quickly soaked up in a gastrointestinal tract, bioavailability of nearly 100%. Communication with blood proteins at the level of 90-95%. Gets through GEB and into cerebrospinal fluid. An elimination half-life — 16 hours. It is removed in the form of a glucuronide mainly with urine. Does not exert impact on process of biotransformation of estrogen, antagonists of vitamin K, progestogens.

Indications to use

  • Treatment of epilepsy of various genesis;
  • Stopping of generalized and partial epileptic seizures, and also convulsive component at organic diseases of a brain;
  • At changes of behavior and character of the patient, caused by epilepsy;
  • Vest, Lennox-Gasto's syndrome;
  • Children's tic and febrile spasms at children;
  • In complex therapy of maniac-depressive psychosis, proceeding with bipolar symptomatology and at inefficiency of purpose of other HP.


High sensitivity to drug, the hepatitis proceeding in an acute or chronic form, pancreas diseases, hemorrhagic diathesis, a porphyria, the I trimester of pregnancy, the expressed thrombocytopenia, the lactation period, age till 3 flyings (for the tableted form).

To take with caution at anemia, a leukopenia, the thrombocytopenia caused by oppression of process of a marrowy hemopoiesis, a renal failure, brain diseases with organic lesions, hypoproteinemias, an inborn fermentopatiya, backwardness of intellectual development of children.

Side effects

Drowsiness, dizziness, headache, dysarthtia, encephalopathy, stupor, enuresis, disturbance of consciousness, change of a mental condition of mood or behavior, (aggression, depression, hallucinations, feeling of fatigue, psychoses, unusual excitement, irritability, motive concern), nausea, vomiting, appetite disturbances, diarrhea, nystagmus, diplopia, anemia, leukopenia, increase or weight reduction, allergic reactions, alopecia, dysmenorrhea, peripheral hypostases, skin rash.

Valparin, application instruction (Way and dosage)

Valparin HR to take a pill without chewing in time or after meal, washing down with water 2-3 times a day. Children are allowed to mix syrup with any liquid or to add to food. It is necessary to use drug in shape by means of a measured cap.

When using drug as mono therapy the initial dose for adults makes 5-15 mg/kg / in days, then it is gradually increased by 5-10 mg/kg / in a week. To children weighing more than 25 kg the similar dose of drug is appointed. The maximum daily dose is equal to 30 mg/kg and at a possibility of monitoring procedure behind its concentration in blood can be increased to 60 mg/kg.

At use of drug in a combination therapy the daily dosage for adult patients makes 10-30 mg/kg with the subsequent its increase on 5-10 mg/kg weekly.

Children with a body weight less than 20 kg of a tablet should not apply. In hard cases the drug can be administered in/in jet or in/in kapelno on 400-800 mg at the rate of 25 mg/kg within 24, 36, 48 hours. During administration of drug reception of drinks which part ethanol is is forbidden. Also, during this period, observance of a diet in connection with risk of increase in body weight is recommended.


Symptoms of overdose are shown by nausea, dizziness, vomiting, a hypomyotonia, diarrhea, breath disturbance, a hyporeflexia, a miosis, a metabolic acidosis, in hard cases — a coma and wet brain.


Drug strengthens action of other HP rendering, antiepileptic action (lamotridzhin, Phenytoinum), antidepressants, antipsychotic drugs (neuroleptics), MAO inhibitors, timoleptik, anxiolytics, barbiturates, ethanol. At joint administration of drug with Primidonum or barbiturates raises concentration of these drugs in blood. Valproic acid increases an elimination half-life of a lamotridzhin and slows down its metabolism, reduces clearance of a zidovudine.

At joint reception of valproic acid with ethanol or drugs, the oppressing TsNS (antipsychotic HP, tricyclic antidepressants, MAO inhibitors) strengthening of oppression of the TsNS functions is noted.

Hepatotoxic HP including ethanol increase risk of development of diseases of a liver. The MAO inhibitors, antidepressants, neuroleptics and other antipsychotic drugs reducing the level of convulsive activity negatively influence efficiency of valproic acid. At a drug combination to salicylates effect of valproic acid, effect of antiagregant and indirect anticoagulants amplifies. Felbamat increases concentration of valproic acid in blood.

At the combined reception with phenobarbital, meflokhiny, Phenytoinum, carbamazepine the metabolism of valproic acid amplifies and its content in blood decreases. Drug does not reduce efficiency of action of oral contraceptives.

Terms of sale

According to the recipe.

Storage conditions

At a temperature up to 25 °C.

Period of validity

36 months.


Depakinum, Apilepsin, Depakinum 300 enterik, Atsediprol, Depakinum horse-radish, Konvulsofin, Dipromal, Everiden, Convulexum, Enkorat, Orfiril, Enkorat hrono.

About Valparin

According to doctors emergence of hrono-forms of Valproatums (Valparin hrono) allowed to reduce considerably risk of emergence of the side effects caused by pinnacled increase of concentration of Valproatum in blood and to increase efficiency of therapy. At the same time, portability of the prolonged forms is comparable with drugs of slow release. Valparin renders to HR the greatest efficiency in therapy of generalized and convulsive toniko-clonic attacks.

Drug is also effective concerning secondary and generalized and partial attacks. Valparin can be used by HR as as mono, and polytherapies of epileptic seizures of various forms of epilepsy, at primary and generalized attacks. Treats drugs of the first row of the choice. It is possible to carry to its advantages also rather low cost of rather original drugs.


  • Valparin hr retard 500 mg No. 100 tabletkitorrent Farmasyyutikals of LTD.
  • Valparin hr retard 300 mg No. 100 tabletkitorrent Farmasyyutikals of LTD.
  • Valparin hr retard 500 mg No. 30 tabletkitorrent Farmasyyutikals of LTD.
  • Valparin hr retard 300 mg No. 30 tabletkitorrent Farmasyyutikals of LTD.

Drugstore of IFC

  • Valparin HR tbl p / about retard 300 mg No. 100, Torrent Pharmaceuticalsindiya
  • Valparin HR tbl p / about retard 500 mg No. 100, Torrent Pharmaceuticalsindiya
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Section: For a nervous system
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Education: Graduated from Sverdlovsk medical school (1968 - 1971) as "Paramedic". Graduated from the Donetsk medical institute (1975 - 1981) as "An epidemiologist, a hygienist". Passed postgraduate study in the Central scientific research institute of epidemiology Moscow (1986 - 1989). An academic degree – the candidate of medical sciences (degree is awarded in 1989, protection – the Central scientific research institute of epidemiology Moscow). Numerous advanced training courses are studied in epidemiology and infectious diseases.

Experience: Work as the manager of department of disinfection and sterilization of 1981 - 1992. Work as the manager of department of especially dangerous infections of 1992 - 2010. Teaching activity at Medical institute 2010 - 2013.

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