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Valgantsiklovira a hydrochloride, krospovidon, povidone, microcellulose, a gidroksipropilmetiltsellyuloza, stearic acid, polyethyleneglycol, titanium dioxide, polysorbate, ferrous oxide, the water purified.
Tablets of 450 mg in a film cover convex an oval form, pink color in polyethylene bottles in cardboard packaging No. 60.
Pharmacodynamics and pharmacokinetics
Drug with antiviral action (pro-medicine) – represents valilovy ether of a gantsiklovir which under the influence of intestinal and liver enzymes after reception is quickly transformed in gantsiklovir. Anti-virus activity of a gantsiklovir is based on suppression of process of synthesis of DNA of viruses by competitive embedding of a deoxyguanosine of triphosphate in structure of DNA that leads to stopping of process of lengthening or very limited lengthening of DNA of viruses.
Gantsiklovir is synthetic analog of the deoxyguanosine which is actively influencing reproduction process reproduction herpes of viruses. Actively influences a virus of a herpes simplex, hepatitis V, TsMV, Epstein-Barre's virus, chicken pox. At prolonged treatment by drug a number of viruses can have a resistance to a gantsiklovir that is caused by processes of mutations and selection.
Valgantsiklovir is well and quickly soaked up from a gastrointestinal tract. In a liver and a wall of intestines valgantsiklovir it is transformed in gantsiklovir. Linkng of a gantsiklovir with blood proteins insignificant. The metabolism happens by hydrolysis to formation of a gantsiklovir. It is removed through kidneys.
Indications to use
- In complex treatment of a tsitomegalovirusny retinitis at patients with AIDS;
- Prevention of the TsMV-infection at patients after an organ transplantation.
To take with caution to patients of advanced age and in the presence of the expressed renal failure.
Fatigue, nausea, diarrhea, vomiting, fever, anemia, neutropenia, abdominal pains, abdominal distention, dyspepsia, an abnormal liver function, ascites, weakness, sinusitis, infections of urinary tract, bronchitis, flu, sleeplessness, paresthesias, a headache, a tremor, spasms, confusion of consciousness, a hallucination, psychotic frustration, hypostases, dermatitis, an itch, night perspiration, pneumonia, cough, cold, spasms in muscles, indistinct sight, arterial hypotension, an arthralgia.
Valtsit, the application instruction (A way and a dosage)
To accept drug of Valtsit inside during food.
To patients with active TsMV a retinitis to accept drug in a dose of 900 mg twice a day for 3 weeks. Further transition to a maintenance therapy — a dosage of 900 mg once a day. At an aggravation of symptoms of the patient to repeat a course of induction therapy.
Valtsit's use at a renal failure — selection of a dose is carried out on the basis of an indicator of clearance of creatinine.
Prevention of TsMV of an infection at the patients who transferred an organ transplantation. The recommended dose — 900 mg of 1 times a day, since 10 days after transplantation and till the 100th day.
Gantsiklovir increases zidovudine AUC, and the zidovudine reduces slightly concentration of a gantsiklovir. Joint reception of a gantsiklovir with a zidovudine increases probability of development of anemia and a neutropenia. Zaltsitabin increases AUC of a gantsiklovir. The concomitant use of a gantsiklovir with the drugs possessing nephrotic or myelotoxic action can strengthen toxic effect of these drugs. Trimethoprimum lowers renal clearance of a gantsiklovir.
Terms of sale
At a temperature up to 30 °C.
Period of validity
Coincidence on the ATH code of the 4th level:
About drug among doctors positive. "… Clinical data demonstrate that "Valtsit" in treatment of a cytomegalovirus is more effective than traditional means, despite a form of production of drug. In prevention of development of the TsMV-infection after a heart transplantation, a liver, kidneys, within the first half a year, at patients, at administration of drug, the indicator of rejection of bodies decreased and the transplant survival indicator about 100 days of rehabilitation increased".
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