Velafaks

Велафакс Drug photo

The description is actual on 05.08.2015

  • Latin name: Velafax®
  • ATH code: N06AX16
  • Active ingredient: Venlafaksin *
  • Producer: Pliva Hrvatskad.o.o. (Republic of Croatia)

Structure

In 1 tablet of a venlafaksin of a hydrochloride 37,5 and 75 mg of a venlafaksin are equivalent.

MKTs, corn starch, iron oxide, silicon dioxide, sodium carboxymethylstarch, talc, magnesium stearate — as excipients.

Release form

Mg tablets 75 and 37,5.

Pharmacological action

Antidepressive.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Antidepressant which mechanism of action is connected with potentiation of transfer of nervous impulse in TsNS. Active ingredient and its metabolite of ODV block the return serotonin reuptake and noradrenaline, reduce adrenergic reactivity of an organism.

Does not possess affinity to muskarinovy, histamine, cholinergic, adrenergic opioid and benzodiazepine receptors. Does not suppress activity of MAO.

Pharmacokinetics

At intake it is well absorbed and Cmax is reached during 2,4 h, and the main metabolite in 4,3 h. Meal slows down absorption for 30 min. without change of size of the maximum concentration. Is exposed to a metabolism in a liver with formation of the main metabolite O-desmetilvenlafaksina (ODV). T 1/2 active agents and ODV — 5 and 11 h.

Metabolites and active agent in not changed look are removed by kidneys. Equilibrium concentration of a venlafaksin and ODV at a multiple dose are reached in 3 days.

Indications to use

Depressions, including with alarm symptoms.

Contraindications

  • hypersensitivity to drug;
  • reception with MAO inhibitors;
  • considerable dysfunctions baking of kidneys;
  • pregnancy;
  • age till 18 flyings.

At the postponed myocardial infarction, arterial hypertension, stenocardia, a convulsive syndrome, a maniacal state, increase of intraocular pressure and the lost weight drug is used with care.

Side effects

Many of the listed below side reactions have dependence on a dose. It is noted that at long administration of drug weight of side effects decreases.

Arise more often

  • deterioration in appetite, nausea, sometimes vomiting, tendency to locks;
  • dizziness, sleeplessness, excitability, hyper tone, paresthesias, tremor, stupor;
  • accommodation disturbances, expansion of pupils;
  • arterial hypertension;
  • increase of level of cholesterol;
  • difficulty of an urination;
  • disturbances of an erection and ejaculation;
  • weakness, perspiration, increased fatigue;
  • skin rash;
  • weight reduction.

Are less often noted

At sharp drug withdrawal fatigue, the increased drowsiness, nausea, frustration of a chair, vomiting, dryness in a mouth, sleeplessness, irritability, alarm, a disorientation, paresthesias can be noted. In a type of it the dose of drug decreases gradually.

Velafaks, application instruction (Way and dosage)

Pill is taken inside during food. The initial dose usually makes 37,5 mg and 2 times a day are accepted. In the absence of effect in several weeks the dose according to the recommendation of the doctor increases to 150 mg/days in two steps.

Prityazhely depressive frustration — 75 mg of 2 times/days, then increase a daily dose by 75 mg of times v3 day before achievement of medical effect. It is necessary to consider that MS a dose — 375 mg. At achievement of effect the dose gradually decreases to minimum effective. The supporting treatment continues more than 6 months. It is in certain cases reasonable to appoint Velafaks of MV who represents the prolonged form of drug and is issued in capsules on 75 and 150 mg.

At a renal and liver failure of easy degree the mode of dosing is not adjusted. At a renal and moderately severe liver failure the dose of drug is lowered by 50% and all dose is accepted 1 time a day. Upon termination of treatment it is recommended to reduce a dose gradually in 1-2 weeks.

Overdose

Overdose is shown by symptoms: sinus or ventricular tachycardia, hypotension, convulsive states, changes of an ECG. The death at overdose and a concomitant use of alcohol is possible.

Treatment is begun with reception of sorbents and purgatives. Vomiting is not caused in a type of danger of aspiration of emetic masses.

The symptomatic treatment is carried out. Specific antidotes are absent.

Interaction

Drug strengthens influence of alcohol on TsNS. Contraindicated joint purpose of MAO and venlafaksin.

At co-administration of Imipraminum and Diazepam the pharmacokinetics of this drug and its metabolite does not change.

At appointment with the Haloperidol its effect amplifies.

Simultaneous use of Clozapine attracts development of side effects.

Risperidon's pharmacokinetics and his active metabolite does not change at use with venlafaksiny.

Cimetidinum oppresses a metabolism of a venlafaksin therefore slight increase of pharmacological activity of drug is noted.

Interaction of a venlafaksin with hypoglycemic and hypotensive drugs has no clinical value.

At reception with Indinavir pharmacokinetic characteristics of the last change, the pharmacokinetics of a venlafaksin does not change. Experience of use of a venlafaksin and electroconvulsive therapy is absent.

Terms of sale

According to the recipe.

Storage conditions

At a temperature up to 25 Pages.

Period of validity

2 years.

Analogs

Velafaks MV, Venlaksor.

About Velafaks

Antidepressants are often used for treatment of attacks of migraine. They exponentiate action of analgetics (and some possess the independent anesthetizing activity), reduce symptoms of a depression which develops at the patient owing to frequent attacks of migraine. Velafaks efficiency/safety therefore often meet About use of this drug on doctor's orders at migraines differs in a proper correlation. It was appointed a course to 1,5 months and after that noticeable decrease in frequency of a headache and its intensity was noted that allowed patients to reduce quantity of analgetics further.

Positive About Velafaks speak about its efficiency at treatment of a depression. In this case drug was accepted quite long time and any significant side reactions which would cause drug withdrawal were not noted.

Some patients note that in the beginning treatments arose loss of appetite, nausea, disturbed sleeplessness and dizziness during the day. In several days these undesirable reactions disappeared. Meet that after the termination of reception can there were suicide thoughts that forced to resume treatment and then to gradually reduce a dose.

Zdravzona

  • Velafaks MV of 150 mg No. 30 kapsulypliva
  • Velafaks MV of 75 mg No. 30 kapsulypliva
  • Velafaks 37,5mg No. 28 tabletkipliva
  • Velafaks 75 mg No. 28 tabletkipliva

Drugstore of IFC

  • Velafaks tbl 37.5mg No. 28, Plivakhorvatiya
  • Velafaks tbl 75 mg No. 28, Plivakhorvatiya
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Section: For a nervous system
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Education: Graduated from Sverdlovsk medical school (1968 - 1971) as "Paramedic". Graduated from the Donetsk medical institute (1975 - 1981) as "An epidemiologist, a hygienist". Passed postgraduate study in the Central scientific research institute of epidemiology Moscow (1986 - 1989). An academic degree – the candidate of medical sciences (degree is awarded in 1989, protection – the Central scientific research institute of epidemiology Moscow). Numerous advanced training courses are studied in epidemiology and infectious diseases.

Experience: Work as the manager of department of disinfection and sterilization of 1981 - 1992. Work as the manager of department of especially dangerous infections of 1992 - 2010. Teaching activity at Medical institute 2010 - 2013.

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