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The description is actual on 30.04.2014
- Latin name: Vero-Amlodipine
- ATH code: C08CA01
- Active ingredient: Amlodipin (Amlodipine)
- Producer: JSC VEROFARM, Russia
The drug tablet Vero-Amlodipin contains 5 (10 mg) an amlodipin (in the form of a bezilat).
Tablets are issued on 10 pieces in the blister, cardboard packaging can contain 1 or 3 blisters.
Tablets Vero-Amlodipin have anti-anginal and anti-hypertensive effect.
Pharmacodynamics and pharmacokinetics
Drug interferes with receipt through membranes of calcium ions in cells of vessels and a myocardium. Arterial pressure decreases as a result of vasodilatation. The anti-anginal effect is provided amlodipiny which expands peripheral arterioles and promotes decrease in OPSS, without causing at the same time reflex tachycardia. Thanks to it the need of a myocardium for oxygen decreases, and the cardiac muscle consumes less energy. Amlodipin promotes increase in delivery of oxygen in all zones of a myocardium at emergence of spasms of coronary arteries.
After reception it is well soaked up from a gastrointestinal tract (the speed of absorption is not influenced by meal). In 6-12 hours reaches in blood of the maximum concentration. Bioavailability – 65-80%. In a liver it is transformed, forming inactive metabolites. It is removed through kidneys (about 60%) and intestines (25%).
Indications to Vero-Amlodipin's use
Drug is appointed at the following diseases:
- arterial hypertension (monotherapy or together with other drugs);
- vasoconstriction or vasospasm;
- stable stenocardia;
- dilatatsionny (not ischemic) cardiomyopathy with the III-IV stage of chronic heart failure;
- vasospastic stenocardia.
Also it is necessary to appoint this medicine in the form of monotherapy or together with anti-anginal drugs that patient who is unreceptive to therapy by beta adrenoblockers or nitrates.
You should not accept drug at arterial hypotension, to children till 18 flyings and at sensitivity to an amlodipin or other dihydropyridines.
At reception of this medicine can arise:
- tachycardia, arrhythmia, hyperemia, heartbeat, peripheral hypostases, short wind, arterial hypotension;
- hyperplasia of gums, sharp abdominal pains, nausea;
- paresthesias, drowsiness, fatigue, dizziness, headache;
- itch, rash.
At the long duration of a course there can be extremity pains.
Application instruction of Vero-Amlodipin (Way and dosage)
To take medicine inside.
For patients with arterial hypertension or stenocardia the minimum daily dose makes 5 mg. Later with need to increase it about 10 mg are possible.
At a dilatatsionny cardiomyopathy it is necessary to begin treatment with a dose of 2,5 mg which it is possible to increase at normal portability of drug to 10 mg.
According to the instruction it is not recommended to exceed a dosage to in 10 mg a day as it is maximum.
Simultaneous reception of an amlodipin with beta adrenoblockers, thiazide diuretics or APF inhibitors does not demand correction of a dose.
Information on symptoms of overdose is not provided.
The hypotensive effect can amplify at a concomitant use with blockers of calcium channels. It result can be observed also when using means for an inhalation anesthesia or an orlistat that it can lead to sharp increase in pressure, hypertensive crisis.
The delay in an organism of sodium and, as a result, decrease in antigipetrenzivny effect is possible at reception with amlodimpiny estrogen and sympathomimetics. It is possible to strengthen anti-hypertensive effect also by means of Amiodaronum or quinidine.
Emergence of symptoms of a neurotoxicity, such as a sonitus, nausea, an ataxy, diarrhea, vomiting, can be caused by carbonate lithium reception along with Vero-Amlodipin.
The concomitant use of an amlodipin with indometacin or other NPVS leads to reduction of anti-hypertensive effect.
To store in the dark, dry place at a temperature no more than 25 °C.
Terms of sale
Is on sale without recipe.
Period of validity
Drug should be accepted about care at a stenosis of the mouth of an aorta, and also a renal failure and a liver.
Correction of a dose is not required to elderly patients.
Amlodipin can be applied to therapy of patients with a dilatatsionny (not ischemic) cardiomyopathy which is followed by chronic heart failure.
At pregnancy and a lactation
Vero-Amlodipin's safety during breastfeeding or pregnancy was not studied.
It is possible to appoint this drug only if risk for the child less, than for health of mother.
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