Drug contains active agent: doxycycline.
Additional components: lactose, magnesium stearate, corn starch, sodium lauryl sulfate, alginovy acid.
Vibramycinum in the form of the capsules packaged in blisters on 10 pieces on one blister in packaging is issued.
Vibramycinum shows antibacterial action.
Pharmacodynamics and pharmacokinetics
The bacteriostatic action consisting in process of inhibition of the biosynthesis of proteins happening at the ribosomalny level is characteristic of the drug Vibramycinum.
High sensitivity to doxycycline is shown by various gram-positive and gram-negative microorganisms, and also the strains showing resistance to other antibiotics, for example, to new penicillin or cephalosporins. Special sensitivity is shown by Haemophilus influenzae – more than 90% and the main intracellular pathogens.
Drug actively influences many causative agents of dangerous infections: plagues, tularemias, legionell, malignant anthrax, brucellas, cholera vibrio, activators of a sap, rickettsiae, chlamydias and others. Some strains a protea, a pyocyanic stick, mushrooms are not sensitive to it.
It is established that this antibiotic to a lesser extent has the oppressing effect on indestinal flora, it is better and more fullly soaked up, keeps effect longer. At the same time antibacterial activity of doxycycline is higher, than at other natural tetracyclines.
The use of food does not influence doxycycline absorption level. High degree of solubility of the main substance in lipids, and also the low affinity directed to binding of Sa2+ is characteristic of drug. Medicine is quickly and fully soaked up from a gastrointestinal tract, depending on the accepted dosage. The maximum concentration as a part of plasma is reached 2 hours later from the moment of reception of a dose of 200 mg.
Communication of Vibramycinum with blood proteins makes not less than 93%. In an organism drug is well distributed in bodies and fabrics, accumulation of therapeutic concentration is found 30-45 minutes later from the moment of reception. Weak penetration into cerebrospinal fluid is noted. Drug is capable to get through a placenta and into maternal milk. Substance is removed from an organism with a stake and urine.
Indications to use
Drug is appointed at treatment of various infections affecting activity:
- respiratory bodies, for example, at pharyngitis, bronchitis and pneumonia, and also ENT organs – at otitis, tonsillitis, sinusitis and other disturbances;
- urinogenital system at not gonorrheal uretrita, inflammations of a neck of uterus, infections of a small pelvis, an epididymite, a proctitis, a venereal granuloma.
And also at conjunctivitis, a sapropyra, fevers, gonorrhea, syphilis, cholera, chancres, trachoma, a psittacosis, a brucellosis, plague and so on.
Reception of Vibramycinum is not recommended at:
Reception of this drug can cause the side effects affecting work of nervous and digestive systems, development of allergic reactions, and also other undesirable actions. At the same time symptoms in a look can be shown: dizzinesses, losses of appetite, nausea, vomiting, diarrhea, glossitis, inflammation of a mucous oral cavity and other places, gastritis, esophagitis, pseudomembranous colitis and hepatotoxic.
Sometimes carrying out prolonged or repeated treatment causes development of superinfections because of reproduction of bacteria or mushrooms, insensitive to drug.
Also emergence of undesirable skin symptoms is not excluded: skin discoloration, rash, dermatitis and so on. Allergic reactions can be shown by rash, urticaria, an eosinophilia, short wind, an anaphylaxis, a Quincke's disease and other disturbances.
Adult patients quite often feel increase of intracranial pressure, a headache, nausea, vomiting, vision disorders.
Vibramycinum, application instruction (Way and dosage)
The dose of drug and duration of treatment is defined by the attending physician. The average daily dosage for adult patients makes 200 mg in an initiation of treatment, then the maintenance dose – 100 mg can be established. It should be noted that for each type of disturbance appoint the corresponding scheme and duration of treatment.
Capsules are swallowed in the whole look, plentifully washing down with liquid. Absorption of drug improves at its reception on a hungry stomach.
At the admission of the next reception of a capsule, it is necessary to accept the passed dose as soon as possible. But if already there passed a lot of time, then it is better to continue use of medicine according to the appointed scheme. Reception of a double dose is not allowed!
At overdose by doxycycline the symptoms relating to side effects can amplify. It demands the accelerated removal of the remains of drug from a digestive tract by carrying out a gastric lavage, reception of absorbent carbon.
Also the additional symptomatic therapy accompanied with monitoring and maintenance of the main functions of an organism can be carried out.
Doxycycline combination to the antacids containing Al3+, Mg2+, Ca2+, and also iron preparations, sodium bicarbonate laxative with magnesium, Colestyraminum and kolestipoly can reduce their action therefore between use of such drugs observe an interval at 3 o'clock.
Suppression of intestinal microflora is capable to lower the prothrombin ratio demanding correction of dosing of indirect anticoagulants.
Drug increases efficiency of anticoagulative derivatives of coumarin, some antidiabetic means which are sulfonilmochevina derivatives. At simultaneous use decrease in doses of these drugs quite often is required.
Combinations with bactericidal antibiotics break development of a cell wall, for example, with penicillin and cephalosporins, reducing their efficiency.
Vibramycinum will be able to reduce efficiency of many oral contraceptives. Therefore at treatment by doxycycline additional effective methods of contraception are required.
At combinations with Retinolum intracranial pressure quite often increases.
Vibramycinum increases toxic action of the Methotrexate or Cyclosporine A.
Simultaneous use with barbiturates, Carbamazepine, Diphenylhydantoin accelerates a metabolism of the main substance, reducing the period of its semi-removal and reducing therapeutic effect. Therefore increase in daily dosing by doxycycline is possible.
Theophylline is capable to cause the by-effects affecting work of a gastrointestinal tract.
To prevent local irritative effect of drug, for example, an esophagitis, gastritis, a gastrointestinal tract ultseration, it is better to accept it in the afternoon, plentifully washing down with liquid.
Development of a photosensitization therefore it is necessary to limit insolation of treatment before and after it for 4-5 days is possible.
Sometimes drug masks syphilis symptoms that demands monthly carrying out serologic assay within 4 months. Use of Vibramycinum can exert impact on results of an indicator of glucose, urobilinigen, catecholamines and protein in urine.
Treatment by doxycycline can lead to development of allergic manifestations and steady microorganisms, such as Candida. At emergence of the undesirable symptoms and infections caused by steady microorganisms, drug is cancelled and begin the corresponding treatment.
Various antibiotics possessing a broad spectrum of activity are capable to cause pseudomembranous colitis. At oppression of normal bacterial flora of a gastrointestinal tract the stick of Clostridium difficile which toxics cause pseudomembranous colitis is capable to develop. Emergence of a digestive disturbance demands the address to the doctor, but not carrying out independent treatment. It is recommended to refrain from use of the drugs capable to brake a peristaltics of intestines and the other fastening means.
Terms of sale
According to the recipe.
Capsules need to be stored in the place dry, dark, cool and unavailable to children.
Period of validity
Analogs of Vibramycinum
Coincidence on the ATH code of the 4th level:
The main analogs are provided by drugs: Vidoktsin, Dovitsin, Doksal, Doksibene, Doksibene of M, Doksilan and Doxycycline.