Винпотропил Drug photo

The description is actual on 18.02.2015

  • Latin name: Vinpotropile
  • ATH code: N06BX
  • Active ingredient: Vinpocetine + Piracetam (Vinpocetine + Piracetam)
  • Producer: Kanonfarm production closed joint stock company (Russia), Enzyme Firm (Russia)


In 1 ml of a concentrate for preparation of infusion solution there is 1 mg of a Vinpocetine, 80 mg of piracetam and inactive connections: ascorbic (5 mg) and amber acids (13,4 mg) disodium sulfite (3 mg) and the distilled water for injections (no more than 1 ml).

In one tablet, coated film type — 10 mg of a Vinpocetine, 800 mg of piracetam and as excipients — a hydrophosphate calcium dihydrate (120 mg), povidone (21 mg), croscarmellose sodium (33 mg), magnesium stearate (7 mg), talc (7 mg), microcrystallic cellulose (102 mg). Opadry II (35 mg) of brown color, a macrogoal, monohydrate of lactose, and also dyes enter a film cover: ferrous oxide red, ferrous oxide black and titanium dioxide.

In one capsule — 5 mg of a Vinpocetine, 400 mg of piracetam, lactose and talc as excipients. The solid gelatinous capsule consists of two parts – the body (gelatin, titanium dioxide and dyes — quinolinic yellow and "Sunset") and lids (gelatin, titanium dioxide and dye an azoruby).

Release form

Vinpotropil is issued in three dosage forms:

  • In the tablets of an oval form having to risk and film coated beige color with a grayish color. In cross section color almost white. Be packed tablets into the blisters expected 10 pieces in a cardboard pack 3, 6 blisters can.
  • In two-color capsules of color yellow with red (lid), containing powder of white or beige color which can include separate crystals and lumps. In cardboard packaging there can be 2, 3, 5, 10 blisters on 10 kaps. or 2, 4, 6, 8 blisters on 15 pieces, a polyethylene bottle on 15, 50 kaps.
  •  In the form of the concentrate intended for preparation of the infusion solution representing transparent liquid. Usually is issued in 5 ml ampoules placed on the planimetric plastic pallet 5 or 10 of ampoules, in their cardboard packaging there are 1 or 2 pieces. Drug can be completed with the scarificator. Ampoules of brown color, are made of glass of the first hydrolytic class, have a break point.

Pharmacological action

Nootropic action and improvement of a blood-groove of a brain.

Pharmacodynamics and pharmacokinetics

Vinpotropil is the combined drug capable to improve a brain blood stream thanks to active agent — a Vinpocetine and to render nootropic effect by means of the active agent which is a part — piracetam.

The Vinpocetine is capable to improve a brain metabolism due to strengthening of consumption of glucose and oxygen, a metabolism of noradrenaline and serotonin, resistance of neurons to a hypoxia, has antioxidant effect. Strengthening of transport of glucose happens through GEB, at the same time processes of disintegration of molecules of glucose become more energetically economical: on an aerobic way Sa2+-zavisimaya of FDE is selektivno blocked and the AMF level, catecholamines, and also – cyclic GMF and ATP of a brain increases. Concerning system of blood — reduces viscosity and aggregation of thrombocytes, increases plasticity of oxygen carriers – erythrocytes, blocks utilization of adenosine by them and activates oxygen return. The strengthened cerebral blood stream does not cause essential changes of system blood circulation. It is established that substance can get through placental and gistogematichesky barriers.

Piracetam is included as active ingredient in Vinpotropil for optimization of integrative activity of a brain: promoting consolidation of memory and speed of spread of activation, communication of hemispheres, does process of training by more effective. Besides, the sedative and psychogogic effect is not observed. Under the influence of HP microcirculation gradually improves and aggregation of the activated thrombocytes is suppressed that has tserebroprotektorny effect at hypoxias, intoxications, influence of an electroshock. On EEG it is visible that α-and β-activities amplify, δ-activity decreases, and expressiveness of a vestibular nystagmus is reduced. At an initial stage of disturbance of cerebral and vascular genesis at advanced and senile age has the expressed effect. Getting through GE and placental barriers, effectively is removed a hemodialysis.

Concentrate pharmacokinetics (parenteral administration)

  • The Vinpocetine reaches therapeutic concentration in plasma of 10-20 ng/ml, at the distribution volume — 5,3 liters on kg, contacts proteins for 66 percent at clearance — 66,7 l/h, has an extrahepatic metabolism. In breast milk within an hour there are 0,25%, time of half-decay of 220-367 min. Elimination kidneys and through intestines (a ratio 3:2).
  • Time of half-decay of piracetam from plasma — 4,5 hours, from a brain — 7,7 hours, from cerebrospinal fluid — 8,5 hours (at a renal failure chronic and terminal it can be extended till 2,5 days). Practically without being exposed to biotransformation, two thirds of substance are removed by kidneys for 30 h, at the general clearance of 80-90 ml. Researches in vivariums showed that substance kumulirutsya selectively in fabrics of bark of hypermarket, basal kernels, in frontal lobes, parietal lobes, occipital shares and in a cerebellum to a large extent.

Pharmacokinetics of tablets and capsules

The maximum concentration of a Vinpocetine is reached in 2–4 hours, and process of absorption happens mainly in initial departments of a gastrointestinal tract. The subsequent intakes cause linear kinetics. Time of half-decay of about 290 min. Whereas bioavailability of piracetam makes about 100%, the maximum concentration of 84 mkg on ml in an hour, repeated primas raises it to 115 mkg on ml.

Indications to Vinpotropil's use

Any of dosage forms is appointed at:

  • insufficiency of cerebral circulation during recovery after the had ischemic or hemorrhagic stroke;
  • parkinsonism of vascular genesis;
  • various intoxications;
  • psychoorganic syndrome where signs of an adynamia and an adynamy prevail.

Use of capsules and concentrate for preparation of infusions effectively at encephalopathies of various genesis, and also alcoholism, brain injuries and other diseases of TsNS which are followed by deterioration intellectual mnesticheskikh functions. Besides, at:

  • asthenic syndrome and Menyer's syndrome;
  • labyrinthopathies.

Additional indications to use of tablets are:

  • chronic circulatory unefficiency of a brain of a hypertensive and posttraumatic origin;
  • symptomatic treatment at dizzinesses;
  • prevention of migraine and sea sickness.


  • hypersensitivity to the making components;
  • the expressed disturbances of a cordial rhythm;
  • heavy course of coronary heart disease;
  • acute phase of a hemorrhagic stroke;
  • renal and/or hepatic insufficiency;
  • deficit of enzyme — lactase, the established lactose intolerance;
  • tablets are contraindicated at glyukozo-galaktozny malabsorption;
  • pregnancy and breastfeeding;
  • age category till 18 flyings.

With care it is necessary to use drug at:

  • disturbances of a hemostasis;
  • heavy bleedings;
  • high-quality hyperbilirubinemias, including at Gilbert's syndrome;
  • viral hepatitis and alcoholic damage of a liver;
  • alcoholism;
  • epilepsies;
  • deficit of enzyme glyukozo-6-fosfatdegidrogenazy (tablet and capsule);
  • to patients of advanced age.

Side effects

Rather various bodies and systems there can be following reactions:

  • CCC: changes of an ECG in the form of a depression of the ST segment, lengthening of an interval of QT, developing of tachycardia, an ekstrasistoliya, deterioration in course of stenocardia, functional mobility of the ABP, inflow.
  • TsNS: sleep disorders, headache, dizziness, excitement, alarm, irritability, decrease in concentration and attention, depression, extrapyramidal frustration, hyperkinesia, spasms, tremor.
  • System of digestion: dryness in a mouth, a gastralgia, heartburn, nausea and vomiting, diarrhea.
  • Sense bodys: lacks of coordination.
  • Integuments: reddening and itch, urticaria or dermatitis.
  • Other: increase of a libido and sexual activity, change of body weight towards increase, the general weakness, the strengthened sweating.

Local reactions which are shown in the form of pains in an injection site and thrombophlebitis can result from Vinpotropil's infusions.

Application instruction of Vinpotropil (Way and dosage)

To prepare solution for infusions take 2–3 amp. drug, 500 ml of 0,9% of solution of sodium of chloride and dekstrozosoderzhashchy solution. It is necessary to enter intravenously on 50–100 ml with a speed not Bol 80 drops in 1 minute once a day. To carry out infusion not later, than in three hours prior to a dream. A standard course of treatment — from 10 days to 2 weeks which if necessary can be repeated in 6–8 weeks. If the expressed improvement is observed, it is possible to pass to other way of reception – inside.

The application instruction of Vinpotropil in tablets: accept inside on 1 tablet 2 or 3 of time during the day, but not later than in 4 hours prior to a dream, and the meal mode does not matter. It is necessary to wash down with enough clear water.

Capsules also accept inside, however, before meal, 1 tab. 2 or 3 of time during the day, but not later than in 4 hours prior to a dream. As a maintenance therapy it is necessary to accept 1 capsule 3 times during the day.

Extent of a course of treatment tablets and capsules fluctuates from 2–3 weeks to 2 months and even half a year. Drug withdrawal demands a gradual dose decline or use of other dosage form, for example, of capsules. Duration of treatment and a dosage should be specified at the attending physician.


Overdose by a Vinpocetine is followed by strengthening of expressiveness of dozozavisimy side reactions. For treatment appoint a gastric lavage, absorbent carbon and symptomatic therapy.

Overdose by piracetam appeals abdominal pains, diarrhea with blood. Treat symptomatic, the hemodialysis in this case is effective for 50–60%. The specific antidote is not found.


  • Geparinoterapiya: increase of risk of development of hemorrhagic complications.
  • Increase of effect of hormones of a thyroid gland.
  • Antipsychotic means (neuroleptics), psychostimulants, indirect anticoagulants — strengthening of effects.
  • Atsenokumarol — decrease in aggregation of thrombocytes, viscosity, the content of fibrinogen and Villebrand's factor.
  • Methyldopum — a potentsiation of hypotensive effect.
  • Anticonvulsant drugs – decrease in efficiency of HP.
  • With care to apply with the substances possessing the central or antiarrhythmic action.

Infusion solution pharmaceutical is compatible to such solutions as: Dextrose (5, 10, 20% percent), fructose (5, 10, 20%), 0,9% Chloride Sodium solution, Ringer's solution, solution of Mannitolum of 20% and hydroxyethylstarch (6, 10%).

Terms of sale

It is released in a drugstore only in the presence of the recipe.

Storage conditions

In the dry dark place, temperature no more than 25 ° Celsius.

List B. For safety of children and animals it is recommended to store in the unavailable place.

Period of validity

Two years from a date of issue.

Analogs Vinpotropil

Analogs of this drug have in structure the same chemical active agents — a Vinpocetine and piracetam, or possess similar pharmacological action:

About Vinpotropile

About Vinpotropile of buyers confirm its efficiency as the nootropic drug capable to improve blood circulation of a brain. They say that the state and the general feeling, and also attention and memory considerably improves and claim that drug costs the money.

Comments of doctors on Vinpotropile are positive, he is used in psychogeriatric practice, he is appointed at various states (for example, intoxications), brain circulatory unefficiencies, and also for prevention of migraine and a sea sickness.


  • Vinpotropil of 5 mg +400mg No. 30 of a kapsulykanonfarm production closed joint stock company
  • Vinpotropil of 5 mg +400mg No. 60 of a kapsulykanonfarm production closed joint stock company
  • Vinpotropil of 5 mg +400mg No. 50 of a kapsulykanonfarm production closed joint stock company
  • Vinpotropil of 1 mg +80mg/ml a concentrate for Preeg. solution for infusions of 5 ml No. 10 of an ampulykanonfarm production closed joint stock company
  • Vinpotropil of 10 mg +800mg No. 60 of a tabletkikanonfarm production closed joint stock company

Drugstore of IFC

  • Vinpotropil kaps No. 30, Kanonfarm Production Zaorossiya
  • Vinpotropil kaps No. 60, Kanonfarm Production Zaorossiya
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Section: For a nervous system
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Education: Graduated from the Nikolaev national university of V. A. Sukhomlinsky, gained the diploma of the specialist with honors as "An embryologist, a cytologist, a histologist". Also, the human physiology and animals, the teacher of biology" graduated from a magistracy majoring in ". The course on discipline "Pharmacology" is with honors passable.

Experience: Worked as the senior laboratory assistant of department of Physiology and biochemistry of the Nikolaev national university of V. A. Sukhomlinsky in 2010 - 2011.

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