Волювен Drug photo

The description is actual on 22.07.2016

  • Latin name: Voluven
  • ATH code: B05AA
  • Active ingredient: Gidroksietilkrakhmal (Hydroxiethyl starch)
  • Producer: Fresenius Kabi Deutschland GmbH (Germany)


In 1000 ml weed (Au 2-hydroxyethyl) - starch of 60 g, sodium of chloride of 9 g.

Release form

Plastic bottles and polymeric bags on 250 ml and 500 ml.

Pharmacological action

Plasma substituting.

Pharmacodynamics and pharmacokinetics


Solution of the hydroxyethyl starch received from amylopectin. The molecular weight of drug — 130000 Yes. The structure, similar to a glycogen, explains insignificant risk of anaphylactic reactions. Drug differs in stability of solution at fluctuations of temperature. Is isooncotic solution therefore at its introduction intravascular liquid increases in proportion to the volume which was entered.


At administration of solution of a molecule are split by α-amylase of blood and are removed by kidneys. Average molecular weight is higher than a threshold of renal filtering. Upon termination of infusion in 30 minutes its concentration in blood — 75% from maximum also decrease to 14% in 6 hours. Molecules of hydroxyethyl starch are brought out of an organism in a day. Elimination half-life 1,4 hours. Essential accumulation of active agent in blood is not revealed. Disturbance of functions of kidneys does not change an elimination half-life.

Indications to use

  • hypovolemia, hypovolemic shock, massive blood loss;
  • normovolemichesky hemodilution for the purpose of reduction of amount of the entered donor blood;
  • therapeutic hemodilution (dilution of blood for improvement of rheological properties of blood, for acceleration of removal of products of an exchange).


  • hypersensitivity;
  • overhydratation and hypervolemia;
  • disturbances of coagulant system;
  • congestive heart failure;
  • condition of dehydration;
  • intracranial bleeding;
  • renal failure with an oliguria or an anury.

Not to apply at patients to whom the hemodialysis is carried out.

Side effects

  • in rare instances — hypersensitivity reactions;
  • increase of level of amylase;
  • skin itch (at use in high doses it is long);
  • cultivation of components of blood;
  • blood coagulation disturbances (seldom).

Volyuven, application instruction (Way and dosage)

Long intravenous infusion at which the first dose of 10-20 ml is entered very slowly is carried out. The daily dose depends on blood loss, the maximum dose for adults — 50 ml/kg of weight a day. For children of 10-18 years — 33 ml/kg of weight. Volyuven enter repeatedly from needs of the patient who is under careful supervision.

It is impossible to allow overloads liquid which risk increases at patients with heart failure and at renal failures. At heavy dehydration the preference is given to saline solutions. Care is necessary at disorders of fibrillation.


It is shown in an overload of blood circulation (fluid lungs) — infusion is stopped and enter diuretics.


Introduction of large volumes influences an agglutination test and yields in a false manner positive takes of blood typing. Increase in level of amylase of serum is possible that it is not connected with pancreas pathology.

Terms of sale

According to the recipe.

Storage conditions

Temperature is up to 25 °C.

Period of validity

3 years.

Volyuven's analogs

Refortan, Infukol, Tetraspan, Stabizol.

About Volyuvena

At massive blood loss the preference is given to drugs, minimum breaking a hemostasis. Derivatives of hydroxyethylstarch (GEK) which structure is similar to a glycogen are such. Inertness and good tolerance of these drugs is explained by it. Today the most perfect is drug Volyuven — GEK of the 3rd generation which provides to 100% the volemichesky effect and therapeutic effect kept till 6 o'clock.

For what drip Volyuven? It is applied to completion of volume of blood. Begin treatment with infusion of crystalloids, and then pass to injection of colloid plasma substitutes. In the subsequent for maintenance of coagulative potential begin transfusion of components of blood.

High performance concerning influence macro is noted — and microcirculation, the minimum influence on a hemostasis (blood coagulation), it does not collect in fabrics, has the best profile of safety and portability. For this reason it is possible to use drug in a dose to 50 ml/kg a day that is very important at big surgeries when there is a need of use of infusion for large volumes. Drug is completely removed by kidneys. It is resolved in pediatrics.

In responses use of this drug at a syndrome of hyper stimulation of ovaries in the EKO program is most often noted.

At excess hormonal stimulation 20 and more follicles and ova ripen, the excess amount of oestradiol is developed that is followed by a pachemia, increase of permeability of vessels, puffiness, increase in volumes of a stomach and sometimes accumulation of liquid in an abdominal cavity. In such cases appoint droppers of albumine and Volyuven.

  • "… All 5 days until replanting dripped Volyuven. Transferred well".
  • "… There was a hyper stimulation syndrome. The dropper with Volyuven, a proteinaceous diet and cranberry drink helped. After the 5th dropper it became better".
  • "… Me this drug dripped next day after a puncture. Transferred well".


  • Volyuven solution for infusions of 6% 500 ml No. 1frezenius of Kabi
  • Volyuven solution for infusions of 6% 250 ml No. 1frezenius of Kabi
  • Volyuven solution for infusions of 6% 250 ml No. 30frezenius of Kabi
  • Volyuven solution for infusions of 6% 500 ml No. 10frezenius of Kabi
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  • Volyuven solution for infusions a bottle 500mlfrezenius (Germany)
Section: For blood
in more detail

Education: Graduated from Sverdlovsk medical school (1968 - 1971) as "Paramedic". Graduated from the Donetsk medical institute (1975 - 1981) as "An epidemiologist, a hygienist". Passed postgraduate study in the Central scientific research institute of epidemiology Moscow (1986 - 1989). An academic degree – the candidate of medical sciences (degree is awarded in 1989, protection – the Central scientific research institute of epidemiology Moscow). Numerous advanced training courses are studied in epidemiology and infectious diseases.

Experience: Work as the manager of department of disinfection and sterilization of 1981 - 1992. Work as the manager of department of especially dangerous infections of 1992 - 2010. Teaching activity at Medical institute 2010 - 2013.

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