Zalasta

• Structure
• Release form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications to use
• Contraindications
• Side effects
• Zalasta, application instruction (Way and dosage)
• Overdose
• Interaction
• Terms of sale
• Storage conditions
• Period of validity
• Analogs
• Responses

Structure

Olanzapine, tsellaktoz, prezhelatinizirovanny starch, silicon dioxide colloid anhydrous, starch corn, magnesium stearate.

Release form

Tablets of a round form 2,5; 5; 7,5; 10; 15; 20 mg biconvex yellow color in the blister on 7 pieces in cardboard packaging No. 28, 56.

Pharmacological action

Antipsychotic.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Neuroleptic (antipsychotic drug) possessing broad pharmacological action.

The main antipsychotic effect of drug is caused by blockade of receptors of mesocortical and mesolimbic system; sedation – is caused by blockade of receptors of a reticular formation of structures of a trunk of a brain; antiemetic action — D2 receptors of a zone of the emetic center; hypothermal action is caused by blockade of receptors of a hypothalamus. Olanzapine reduces manifestations productive (hallucinations, nonsense) and negative symptomatology (suspiciousness, hostility, social autism) of psychoses. Extrapyramidal disturbances are noted extremely seldom.

Pharmacokinetics

Olanzapine has high absorption which does not depend on meal. Cmax in blood — after 8 hours. Linkng with proteins (albumine and glycoprotein) high, about 93%. Drug gets through GEB. It is metabolized in a liver, removed with urine kidneys in the form of metabolites.

Indications to use

Treatment of schizophrenia and prevention of recurrence of episodes of mania at bipolar disorder.

Contraindications

High sensitivity to drug, age till 18 flyings, intolerance of a galactose, the period of pregnancy and a lactation, closed-angle glaucoma.

To appoint with care at diseases of kidneys and a liver with the expressed functional disturbances, prostate adenoma, existence in the anamnesis of a convulsive syndrome, epilepsy, a leukopenia, cerebrovascular and cardiovascular diseases, heart failure, at mpozhily age.

Side effects

Arterial hypotension, drowsiness, dizziness, dyskinesia, parkinsonism, dryness in a mouth, locks, appetite increase, an adynamy, increase in body weight, an eosinophilia, skin rash, an itch, the small tortoiseshell, hypostases, disturbances of gait, falling, fervescence, visual hallucinations.

Zalasta, application instruction (Way and dosage)

To accept inside once a day, irrespective of meal. An initial dosage of drug at schizophrenia — 10 mg/days. When stopping episodes of mania — 10-20 mg/days in one step, at use of drug as monotherapy or as a part of combined treatment — 10 mg/days.

Depending on a condition of the patient the dose can change. For the purpose of prevention of recurrence in the presence of bipolar disorders in a condition of remission the initial dose of drug makes 10 mg/days. At drug withdrawal the dose decline has to be gradual.

Overdose

At overdose olanzapine the most frequent symptoms are excitement/aggression, extrapyramidal symptoms, tachycardia, decrease in level of consciousness up to a coma; more rare — convulsions, a delirium, a coma, respiratory depression, changes of arterial pressure, aspiration, cardiac arrhythmias. At acute overdose at administration of drug in a dose of 450 mg the lethal outcome is possible.

Interaction

The concomitant use of drug with absorbent carbon as absorption of olanzapine decreases by 50-60% is not recommended. Olanzapine weakens efficiency of agonists of a dopamine. To be careful at joint reception with other HP of the central action. Zalasta's reception with alcohol can exponentiate depressive effect of drug on TsNS.

Terms of sale

Prescription issue.

Storage conditions

At a temperature up to 30 °C.

Period of validity

3 years.

Analogs

Finlepsinum, Eglonyl, Rispaksol, Egolanza, Klozasten, Klopiksol Depo, Tiodazin, Parnasan.

About Zalasta

According to doctors, Zalast treats drugs with the expressed antipsychotic action, possesses high performance in the relation of both positive, and negative symptomatology. The effect of drug at prevention of aggravations at patients with schizophrenia is higher, than at drugs of traditional anti-psychotics. Also, positive dynamics at appointment is noted it to patients with bipolar affective disorders.