Заласта Drug photo

The description is actual on 19.07.2016

  • Latin name: Zalasta
  • ATH code: N05AH03
  • Active ingredient: Olanzapine (Olanzapine)
  • Producer: KRKA POLSKA, Sp.z.o.o (Poland)


Olanzapine, tsellaktoz, prezhelatinizirovanny starch, silicon dioxide colloid anhydrous, starch corn, magnesium stearate.

Release form

Tablets of a round form 2,5; 5; 7,5; 10; 15; 20 mg biconvex yellow color in the blister on 7 pieces in cardboard packaging No. 28, 56.

Pharmacological action


Pharmacodynamics and pharmacokinetics


Neuroleptic (antipsychotic drug) possessing broad pharmacological action.

The main antipsychotic effect of drug is caused by blockade of receptors of mesocortical and mesolimbic system; sedation – is caused by blockade of receptors of a reticular formation of structures of a trunk of a brain; antiemetic action — D2 receptors of a zone of the emetic center; hypothermal action is caused by blockade of receptors of a hypothalamus. Olanzapine reduces manifestations productive (hallucinations, nonsense) and negative symptomatology (suspiciousness, hostility, social autism) of psychoses. Extrapyramidal disturbances are noted extremely seldom.


Olanzapine has high absorption which does not depend on meal. Cmax in blood — after 8 hours. Linkng with proteins (albumine and glycoprotein) high, about 93%. Drug gets through GEB. It is metabolized in a liver, removed with urine kidneys in the form of metabolites.

Indications to use

Treatment of schizophrenia and prevention of recurrence of episodes of mania at bipolar disorder.


High sensitivity to drug, age till 18 flyings, intolerance of a galactose, the period of pregnancy and a lactation, closed-angle glaucoma.

To appoint with care at diseases of kidneys and a liver with the expressed functional disturbances, prostate adenoma, existence in the anamnesis of a convulsive syndrome, epilepsy, a leukopenia, cerebrovascular and cardiovascular diseases, heart failure, at mpozhily age.

Side effects

Arterial hypotension, drowsiness, dizziness, dyskinesia, parkinsonism, dryness in a mouth, locks, appetite increase, an adynamy, increase in body weight, an eosinophilia, skin rash, an itch, the small tortoiseshell, hypostases, disturbances of gait, falling, fervescence, visual hallucinations.

Zalasta, application instruction (Way and dosage)

To accept inside once a day, irrespective of meal. An initial dosage of drug at schizophrenia — 10 mg/days. When stopping episodes of mania — 10-20 mg/days in one step, at use of drug as monotherapy or as a part of combined treatment — 10 mg/days.

Depending on a condition of the patient the dose can change. For the purpose of prevention of recurrence in the presence of bipolar disorders in a condition of remission the initial dose of drug makes 10 mg/days. At drug withdrawal the dose decline has to be gradual.


At overdose olanzapine the most frequent symptoms are excitement/aggression, extrapyramidal symptoms, tachycardia, decrease in level of consciousness up to a coma; more rare — convulsions, a delirium, a coma, respiratory depression, changes of arterial pressure, aspiration, cardiac arrhythmias. At acute overdose at administration of drug in a dose of 450 mg the lethal outcome is possible.


The concomitant use of drug with absorbent carbon as absorption of olanzapine decreases by 50-60% is not recommended. Olanzapine weakens efficiency of agonists of a dopamine. To be careful at joint reception with other HP of the central action. Zalasta's reception with alcohol can exponentiate depressive effect of drug on TsNS.

Terms of sale

Prescription issue.

Storage conditions

At a temperature up to 30 °C.

Period of validity

3 years.


Finlepsinum, Eglonyl, Rispaksol, Egolanza, Klozasten, Klopiksol Depo, Tiodazin, Parnasan.

About Zalasta

According to doctors, Zalast treats drugs with the expressed antipsychotic action, possesses high performance in the relation of both positive, and negative symptomatology. The effect of drug at prevention of aggravations at patients with schizophrenia is higher, than at drugs of traditional anti-psychotics. Also, positive dynamics at appointment is noted it to patients with bipolar affective disorders.


  • Zalasta of 10 mg No. 28 tabletkikrka Polsk Sp.z.o.o.
  • Zalasta ku-tab 10 mg No. 28 of a tablet for rassasyvaniyakrka Polsk Sp.z.o.o.
  • Zalasta ku-tab 5 mg No. 28 of a tablet for rassasyvaniyakrka Polsk Sp.z.o.o.
  • Zalasta of 5 mg No. 28 tabletkikrka Polsk Sp.z.o.o.

Drugstore of IFC

  • Zalasta tbl 5 mg No. 28, KRKA of Polsk of Sp.zo.o. Poland
  • Zalasta tbl 10 mg No. 28, KRKA of Polsk of Sp.zo.o. Poland
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Section: For a nervous system
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Education: Graduated from Sverdlovsk medical school (1968 - 1971) as "Paramedic". Graduated from the Donetsk medical institute (1975 - 1981) as "An epidemiologist, a hygienist". Passed postgraduate study in the Central scientific research institute of epidemiology Moscow (1986 - 1989). An academic degree – the candidate of medical sciences (degree is awarded in 1989, protection – the Central scientific research institute of epidemiology Moscow). Numerous advanced training courses are studied in epidemiology and infectious diseases.

Experience: Work as the manager of department of disinfection and sterilization of 1981 - 1992. Work as the manager of department of especially dangerous infections of 1992 - 2010. Teaching activity at Medical institute 2010 - 2013.

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