Zinnat

Зиннат Drug photo

The description is actual on 27.05.2016

  • Latin name: Zinnat
  • ATH code: J01DC02
  • Active ingredient: Tsefuroksim (Cefuroxime)
  • Producer: Glaxo Operations UK Limited (Great Britain)

Structure

As a part of tablets Zinnat of 125 mg contains active component of a tsefuroksim aksetit (125 mg in terms of tsefuroksy). Zinnat 250 mg also contain tablets in structure active component of a tsefuroksim aksetit (250 mg in terms of tsefuroksy). Besides, as a part of medicine there are additional components: MKTs, croscarmellose sodium, sodium lauryl sulfate, colloid silicon dioxide, the vegetable hydrogenated oil.

Contains granules from which suspension Zinnat prepares in structure of a tsefuroksim aksetit as active agent, and also additional ingredients: stearic acid, sucrose, aspartame, to potassium atsesulfa, K30 povidone, gum xanthane, fragrance.

Release form

The antibiotic Zinnat is issued in the form of tablets and granules from which prepare suspension.

  • Tablets with white or almost white film cover, a form oval, biconvex. On the one hand have an engraving of "GXES5" (a dose of 125 mg), "GXES7" (a dose of 250 mg). In a section the tablet has white or almost white color. Contain in the blister on 5 or 10 pieces in a cardboard box — 1 or 2 bl.
  • Granules – the grains having irregular shape, the different size, but it is no more than 3 mm. Color – white or almost white. After cultivation white or light yellow suspension which has fruit aroma is formed. Granules contain in bottles from dark glass, 125 mg / 5 ml. The bottle is closed by a cover from the plastic equipped with the device against opening by children. The measured spoon is also put in a cardboard pack.

Pharmacological action

Aksetit substance of a tsefuroksim - it is the predecessor of a tsefuroksim belonging to the second generation of tsefalosporinovy antibiotics. Shows activity in relation to a wide range of activators, including to the strains producing β-lactamelements.

Resistance of a tsefuroksim to influence bacterial β-лактамаз therefore substance is effective on the relation of ampitsillinrezistentny or amoksitsillinrezistentny strains is noted. Exerts bactericidal impact which is connected with process of suppression of synthesis of a cell wall of bacteria owing to linkng with the main proteins targets.

Activity of a tsefuroksim of in vitro in relation to a number of gram-negative aerobes, gram-negative aerobes, anaerobe bacterias is noted (cocci gram-positive and gram-negative, gram-positive and gram-negative sticks, gram-negative spirochetes).

To a tsefuroksim such microorganisms are insensitive: Pseudomonas spp., Clostridium difficile, Acinetobacter calcoaceticus, Campylobacter spp., strains of Staphylococcus aureus and Staphylococcus epidermidis, which rezistentna to Methicillinum, Legionella spp., Listeria monocytogenes. To active agent of drug Zinnat separate strains of such childbirth are also insensitive: Morganella morganii, Enterococcus (Streptococcus) faecalis, Serratia spp., Citrobacter spp., Proteus vulgaris, Bacteroides fragilis, Enterobacter spp.

Pharmacokinetics and pharmacodynamics

After medicine was taken orally, there is a slow process of absorption of substance of a tsefuroksim aksetit from a digestive tract. Substance is quickly hydrolyzed with release of a tsefuroksim in mucous a small bowel and in blood. Gets through a placenta, GEB, gets to breast milk. Optimum absorption of medicine happens if to accept it at once after food.

The greatest concentration of active agent after reception of tablets is noted approximately later 2,4 h provided that medicine was taken after food.

The greatest concentration after reception of suspension is noted approximately in 2-3 hours on condition of drug intake after food.

With proteins of plasma communication approximately for 33–50%.

Tsefuroksy is not exposed to a metabolism in an organism.

Time of semi-removal is equal to 1-1,5 h. It is excreted by canalicular secretion and glomerular filtering. At a dialysis serumal concentration of substance decrease.

Indications to use

Tablets and suspension Zinnat are shown to use for the purpose of impact on a wide range of gram-positive and gram-negative bacteria. It is applied for the purpose of treatment of the diseases of infectious and inflammatory character provoked by bacteria which are sensitive to a tsefuroksim:

  • infectious diseases of ENT organs and upper respiratory tracts (sinusitis, average otitis, pharyngitis , etc.);
  • infectious diseases of the lower respiratory tracts (bronchitis, pneumonia, aggravation of a chronic form of bronchitis);
  • infectious diseases of soft tissues and skin (furunculosis, pyoderma, etc.);
  • infectious diseases of urinary tract (pyelonephritis, cystitis, urethritis, etc.);
  • Lyme's illness in its early stage, prevention of development of late stages of this illness in patients of 12 flyings;
  • gonorrhea;
  • meningitis;
  • peritonitis;
  • sepsis.

Contraindications

Zinnat it is contraindicated to take all dosage forms of drug at hypersensitivity to β-laktamny antibiotics (in the presence in the anamnesis of sensitivity to tsefalosporinovy antibiotics, karbapenema, penicillin).

Zinnat children under 3 years cannot take a pill.

The suspension prepared from granules is not appointed to people at whom hypersensitivity to aspartame, a fenilketonuriya is noted. Also it is impossible to apply this form of an antibiotic to treatment of children till 3 months.

Carefully Zinnat appoint at diseases of the alimentary system (including in the anamnesis), ulcer colitis, disturbances of functions of kidneys, and also at pregnancy and feeding breast milk.

Side effects

As a rule, drug with active agent of a tsefuroksim aksetit negative reactions at treatment are not considerable, they are reversible and short. Such side effects can be noted:

  • superinfection sort Candida mushrooms;
  • lymphatic and hemopoietic systems: an eosinophilia, thrombocytopenia, false positive test of Koombs, a leukopenia, seldom or never — hemolitic anemia;
  • immune system: manifestations of hypersensitivity reactions in the form of rash on skin, small tortoiseshells, an itch, seldom or never — a serum disease, medicinal fever, an anaphylaxis;
  • nervous system: headaches, dizziness;
  • alimentary system: dysfunctions of a gastrointestinal tract which are shown by diarrhea, nausea, an abdominal pain, sometimes – vomiting, in rare instances — pseudomembranous colitis;
  • zhelchevyvodyashchy ways and liver: tranzitorny increase of activity of liver enzymes, in rare instances – hepatitis, jaundice (generally cholestatic);
  • integuments, hypodermic fatty tissue: seldom or never — a multiformny erythema, Stephens-Johnson's syndrome.

Application instruction of Zinnat (Way and dosage)

The antibiotic Zinnat needs to be applied only on doctor's orders.

Tablets Zinnat, application instruction

As a rule, it is necessary to accept medicine in the form of tablets 7 days, but duration of a course can make from 5 to 10 days. It is recommended to drink tablets after meal.

To adult patients at the majority of infectious diseases appoint 250 mg of means Zinnat 2 times a day. At treatment of infectious diseases of urinary tract is shown to accept 125 mg of means of 2 rubles a day. At infectious diseases of the lower respiratory tracts and moderately severe appoint easy 250 mg of means Zinnat 2 times a day, at a serious illness increase a dose to 500 mg 2 ruble a day. At an uncomplicated form of gonorrhea the single dose of 1 g of means is shown.

For treatment of an illness of Lyme appoint 500 mg of 2 rubles a day, the course of treatment lasts 20 days.

To children since three years at the majority of diseases appoint 125 mg of drug Zinnat 2 rubles a day. The greatest daily dose — 250 mg. At treatment of average otitis or serious infectious diseases the doctor can appoint reception of 250 mg of 2 rubles a day. An admissible dose in days — 500 mg

Suspension Zinnat, application instruction

Suspension is applied to children inside, reception for children of 3 months is shown.

In most cases the doctor appoints reception of a dose of 125 mg of 2 rubles a day. Reception of 250 mg twice a day, but no more than 500 mg a day is shown to children after achievement of two-year age at treatment of average otitis or serious infectious diseases.

In case of purpose of drug to babies the dose is calculated taking into account age of the child and his body weight. As a rule, to children of 3 months appoint 10 mg of funds for 1 kg of the weight of 2 rubles a day. At heavy infections the dose can be increased to on 15 mg by 1 kg of the weight of 2 rubles a day, but the child should not accept more than 500 mg of medicine a day.

Overdose

In case of overdose of medicine a hyperexcitability of a brain up to spasms can develop. In that case carry out symptomatic therapy taking into account that concentration of a tsefuroksim in serum decrease when carrying out a peritoneal dialysis and hemodialysis.

Interaction

Bioavailability of a tsefuroksim can go down at a concomitant use of drugs which reduce acidity of a gastric juice. Such drugs level effect of increase of absorption of medicine at reception after food.

Zinnat can influence a condition of intestinal microflora, and it leads to reduction of a reabsorption of estrogen. As a result action of the hormonal peroral combined contraceptives decreases.

As owing to carrying out the ferrotsianidny test the false-negative result is possible to determine glucose level in blood and in plasma it is desirable to apply hexokinase or glyukozooksidazny methods.

Reception of means Zinnat does not make impact on quantitative definition alkaline pikratnym by a creatinine method.

At simultaneous use with loopback diuretics canalicular secretion, renal clearance decreases, concentration of a tsefuroksim in plasma, and also its time of semi-removal increases.

At reception along with diuretics and aminoglycosides the probability of development of nephrotoxic effects increases.

Terms of sale

Zinnat is implemented according to the recipe.

Storage conditions

Tablets and granules store at a temperature no more than 30 °. Ready suspension needs to be stored in the refrigerator, temperature at the same time has to make 2-8 °C. It is necessary to protect all forms of means Zinnat from children.

Period of validity

It is possible to store tablets Zinnat 3 years, granules — 2 years. Period of storage of ready suspension – is no more than 10 days.

Special instructions

It is necessary to be careful at purpose of an antibiotic to people at whom allergic reaction to a beta laktamnye antibiotics in the anamnesis is noted.

During treatment it is important to monitor function of kidneys. It follows is charming to do to those patients who receive high doses of medicine.

In the course of treatment at patients false positive reaction of urine to glucose can be noted.

At long use of an antibiotic Zinnat is possible the active growth of mushrooms of the sort Candida. Also at long treatment there can be a growth of some other resistant microorganisms. The therapy termination is in that case reasonable.

As in the course of treatment by antibiotics of a wide range of influence pseudomembranous colitis can develop, it is important to carry out differential diagnosis of pseudomembranous colitis at people at whom heavy diarrhea during treatment by antibiotics or after the termination of a course of therapy is noted.

At treatment by drug Zinnat of borreliosis can be observed Yarisha-Gerksgeymer's reaction which is connected with bactericidal activity of drug concerning Borrelia burgdorferi spirochete. It is necessary to inform patients on a possibility of development of similar symptoms.

If for 3 days after an initiation of treatment the clinical effect was not noted, it is necessary to continue administration of drug.

It is impossible to crumble or break tablets Zinnat. Therefore such form of medicine is not appointed to small children, and also those patients at whom difficulties of swallowing are noted.

The people who are ill a diabetes mellitus have to consider that in 5 ml of ready suspension Zinnat contains 0,25 XE.

As at reception of a tsefuroksim aksetit can provoke development of dizziness, it is necessary to warn patients about need to carefully drive transport and to be engaged in potentially dangerous types of activity.

Zinnat's analogs

Coincidence on the ATH code of the 4th level:

Analogs of this medicine are drugs: Aksosef, Antibioksim, Zinatsef, Zinoksimor, Ksorim, Tsefurabol, Tsefurozin, Tsefuroksim of sodium, aksetit Tsefuroksim, etc. Only the attending physician after establishment of the correct diagnosis can pick up Zinnat's analogs children.

Zdravzona

  • Zinnat of 125 mg No. 10 of a tablet
  • Zinnat of a granule for suspension 125mg/5ml 50mlglakso of Opereyshns Great Britain Ltd.
  • Zinnat of 250 mg No. 10 of a tablet

Drugstore of IFC

  • Zinnat tbl p / about 250 mg No. 10 *, Glaxo Wellcomevelikobritaniya
  • Zinnat susp.orat. 125mg/5ml fl 50 ml, Glaxo Wellcomevelikobritaniya
  • Zinnat tbl p / about 125 mg No. 10, Glaxo Wellcomevelikobritaniya
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Apteka24

  • Zinnatglaxo Operations UK (Great Britain)
  • Zinnatglaxo Operations UK (Great Britain)
  • Zinnataniya)
  • Zinnatglaxo Operations UK (Great Britain)
  • Zinnat of the tab. of 500 mg No. 10glakso Welkom GW (Great Britain)

Paniapteka

  • Zinnat gr.d/prig.susp. 125 mg of a sachet No. 14glakso Welkom
  • Zinnat gr.d/prig.susp. 125 mg of a sachet No. 14glakso Welkom
  • Zinnat gr.d/prig.susp. 125 mg of a sachet No. 14glakso Welkom

BIOSPHERE

  • Zinnat of 125 mg / 5 ml of 50 ml gran.d/susp. for intake
  • Zinnat of 250 mg No. 10 tabl.p.o.glaxo Wellcome Operations (Great Britain)
  • Zinnat of 125 mg No. 10 tabl.p.o.
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Section: Antibiotics
in more detail

Education: "Pharmacy" graduated from the Rovno state basic medical college majoring in. Graduated from the Vinnytsia state medical university of M. I. Pirogov and internship on its base.

Experience: From 2003 to 2013 – worked at positions of the pharmacist and manager of a pharmaceutical booth. It is awarded by diplomas and distinctions for long-term and honest work. Articles on medical subject were published in local editions (newspaper) and on various Internet portals.

PAY ATTENTION! Information on drugs on the website is help generalizing, collected from public sources and can form the basis for making decision on use of medicines it is not aware of treatment. Before medicine use Zinnat surely consult with the attending physician.